174 Children With COVID-19 Developed MIS-C, 4 Died!

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174 children in Malaysia developed MIS-C, after contracting COVID-19… and four died!

Find out what MIS-C is all about, and why it’s so dangerous to children with COVID-19.


Children COVID-19 Are At Risk Of Developing MIS-C

Many children who get infected with COVID-19 run the risk of getting MIS-C, which is short for Multisystem Inflammatory Syndrome in Children.

MIS-C is a condition in which multiple organs in the child becomes inflamed – heart, lungs, kidneys, brain, eyes, and the gastrointestinal organs.

While COVID-19 may generally be mild for children, many of those who develop MIS-C require ICU care and even then, it can turn deadly.

174 Children With COVID-19 Developed MIS-C, 4 Died!


174 Children With COVID-19 Developed MIS-C, 4 Died!

On 19 February 2022, the Multisystem Inflammatory Syndrome in Children (MIS-C) Malaysia Study Group released their results.

The group looked at MIS-C cases in 14 Malaysian hospitals from June 2020 to December 2021, and here was what they found :

  • 174 children with COVID-19 suffered from MIS-C
  • 100 (57%) of them were children 5-11 years in age
  • The majority of cases required PICU (Paediatric Intensive Care Unit) care
  • 7 (4%) of them died, despite getting PICU care

Here is the breakdown of those cases by age groups :

Age Group MIS-C Cases
< 1 year old 25 (14.4%)
1 to < 5 years old 38 (21.8%)
5 to < 9 years old 64 (36.8%)
9 to < 12 years old 36 (20.7%)
≥ 12 years old 11 (6.3%)

While the risk of developing MIS-C from COVID-19 is low, the consequences are serious.

The majority of children developing MIS-C from COVID-19 required PICU care, and despite getting that, seven (4%) of them died.

Shockingly, all of the affected children had left ventricle dysfunction, with 68% developing shock and almost 29% developing cardiac failure requiring VA ECMO – a heart-lung machine.

Here is the breakdown of symptoms seen in children who developed MIS-C after contracting COVID-19.

MIS-C Conditions /
Treatment Required
Fever > 4 days + Asthenia * 100%
Left ventricle dysfunction
– Shock
– Coronary dilatation
– Pericarditis
Bulbar conjunctivitis 89%
Digestive Involvement
– Nausea, diarrhoea
– Exploratory laparascopy
Cervical + mesenteric
Skin rash 57%
Red and cracked lips 54%
Neurological signs 31%
Respiratory signs 34%

* Asthenia = generalised physical weakness or lack of energy


MIS-C In Children With COVID-19 : What To Look For?

Parents of children who contract COVID-19 should keep a vigilant eye out for potential symptoms of MIS-C.

Please see medical attention if your child has ongoing fever, with at least one of these symptoms :

  • stomach pain
  • bloodshot eyes
  • diarrhoea
  • dizziness or lightheadedness
  • skin rash
  • vomiting

Parents should also seek emergency care, if their child develops :

  • breathing difficulties
  • persistent pain or pressure in the chest
  • confusion
  • inability to wake, or stay awake
  • pale, grey, or blue-coloured skin, lips or nail beds


How To Prevent MIS-C In Children With COVID-19?

The easiest and most effective way to prevent MIS-C in children, is to prevent them getting COVID-19 in the first place.

COVID-19 preventive measures like wearing face masks + face shield, as well as maintaining social distance and hand hygiene work.

However, those measures can only do so much against highly-contagious variants. It is also very important that children be fully-vaccinated against COVID-19.

The approved Pfizer paediatric vaccine for COVID-19 is 90% effective in preventing COVID-19 in children 5-11 years in age, while the Pfizer vaccine for adolescents and adults are 95% effective against COVID-19.

So protect your children against MIS-C, by vaccinating them against COVID-19!

Read more : What To Do Before, During, After COVID-19 Vaccine For Kids!

What To Do Before, During, After COVID-19 Vaccine For Kids!


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Dr. Adrian Wong has been writing about tech and science since 1997, even publishing a book with Prentice Hall called Breaking Through The BIOS Barrier (ISBN 978-0131455368) while in medical school.

He continues to devote countless hours every day writing about tech, medicine and science, in his pursuit of facts in a post-truth world.


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