Can Foreign DNA In mRNA Vaccines Change Our DNA?!

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Can foreign DNA enter our cells through mRNA vaccines, and change our DNA and humanity forever?!

Take a look at the viral claim, and find out what the facts really are!

 

Claim : Foreign DNA In mRNA Vaccines Can Change Our DNA!

People are sharing a video clip of Tucker Carlson interviewing Florida Surgeon General Joseph Ladapo, which claims or suggestions that foreign DNA can enter our cells through the mRNA vaccines and change our DNA and humanity forever!

Tucker Carlson : Could foreign DNA enter your cells through the mRNA COVID vax and change your DNA — and humanity itself — forever? Sounds nutty. It’s not. “Absolutely that could happen,” says Dr. Joseph Ladapo, the surgeon general of Florida. A shocking conversation.

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Truth : Foreign DNA In mRNA Vaccines Cannot Change Our DNA!

Let’s take a closer look at these claims about foreign DNA fragments in mRNA vaccines changing our DNA, and find out what the facts really are!

Fact #1 : Ladapo Claims Were Refuted By FDA Earlier

First, I should point out that Joseph Ladapo’s claims about foreign DNA fragments changing our DNA have already been refuted by the US Food & Drug Administration (FDA) on 14 December 2023 (PDF).

Here’s a quick summary of what Dr. Peter Marks, Director of the FDA’s Center for Biologics Evaluation and Research replied to Ladapo’s claims:

  1. After a “thorough assessment of the entire manufacturing process, FDA is confident in the quality, safety, and effectiveness of the COVID-19 vaccines“.
  2. No safety concerns regarding “residual DNA” were identified after over a billion doses of mRNA vaccines being administered.
  3. Animal studies using the mRNA vaccine with residual DNA demonstrated “no evidence for genotoxicity from the vaccine“.
  4. Pharmacovigilance data from hundreds of millions of vaccinated people also showed “no evidence” of genotoxicity from the mRNA vaccines.
  5. Reproductive toxicology studies to test the possible integration of residual DNA fragments in reproductive cells found “no concerns” with the mRNA COVID-19 vaccines.

As you can see, the FDA had already addressed Ladapo’s claims about testing the mRNA vaccines for DNA integration.

The FDA reply (PDF) was also succinct – just two pages long, and did not divert to irrelevant topics like “what time the sun sets in China” or “their third cousin’s Bar Mitzvah” as Ladapo claims in the Tucker Carlson interview.

So the question you should be asking is – why is Joseph Ladapo still flogging these claims, when the FDA has clearly stated that tests were conducted on mRNA vaccines, and have shown them to be safe and effective, and that they do not pose any DNA integration (genotoxicity) risks?

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Fact #2 : FDA Guidelines Were For DNA Vaccines

In the Tucker Carlson interview, Ladapo claimed or suggested that the FDA did not mention its own guidance on DNA contamination. That’s not true.

The FDA letter to Ladapo (PDF) actually addressed his claims, pointing out that the guidance (PDF) only applied to DNA vaccines, not mRNA vaccines. Even the name clearly states that the guidance was meant for DNA vaccines.

In your letter, you raise questions, citing to the 2007 Guidance for Industry: Considerations for Plasmid DNA Vaccines for Infectious Disease Indications. This guidance was developed for DNA vaccines themselves, not for DNA as a contaminant in other vaccines, and is not applicable to the mRNA COVID-19 vaccines.

DNA vaccines work by introducing a DNA sequence into the cell nucleus, so DNA contamination would be a real concern. In contrast, mRNA vaccines do not enter the cell nucleus, so DNA contamination isn’t a real concern.

It is unknown if Ladapo understands the difference between DNA and mRNA vaccines. But it’s clear that the FDA already informed him that the guidance he quoted was not relevant.

It’s like a bit like quoting the manual for a motorcycle as “evidence” that his diesel truck only needs two wheels, instead of four. So why does he still persist in mentioning the FDA guidance?

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Fact #3 : Smaller Fragments Are Harder To Filter

Ladapo claims that there are billions to hundreds of billions of foreign DNA fragments in each dose of the mRNA vaccine. That sounds scary, doesn’t it? The truth is – it’s really a red herring.

The DNA fragments in mRNA vaccines are produced as a result of its manufacturing process using a DNA template. After the DNA template creates the mRNA vaccine, DNAse is used to break down the residual DNA into tiny fragments.

Focusing on the number of these DNA fragments is also wrong, as you want the DNAse enzyme to really do a good job and cut up the residual DNA into tiny pieces. Naturally, the more you cut DNA up into smaller fragments, you get more (but smaller) fragments. It is consequently harder to filter these smaller fragments out, but the smaller they are, the less likely they are biologically active.

Think of residual DNA as parts of the mRNA factory that was dismantled once the vaccine was manufactured. If you chop it up real good, you get nothing more than small pieces of scrap metal. Sure, the disposal team may have left a couple of bolts and screws lying on the floor, but can they be used to recreate the factory? No.

Fact #4 : mRNA Vaccines Meet DNA Fragment Limit

Instead of focusing on the “number” of DNA fragments, it makes much more sense to focus on the “total weight” of residual DNA, and the “size” of those fragments.

Currently, the WHO and US FDA guidelines recommend that residual DNA in vaccines and other biological products should not exceed 10 nanograms (ng) per purified dose, and the DNA fragments should be no greater than 200 bp in length.

Even that limit appears to be out of an abundance of caution, as studies have not shown any actual danger from residual DNA, as they are tiny fragments.

In its December 2023 reply (PDF), the FDA actually pointed out to Ladapo that the amount of residual DNA fragments was less than 1/1000 the amount of mRNA in each vaccine dose.

The specification for the COVID-19 mRNA vaccines for residual DNA following DNAse treatment results in the presence of DNA fragments at a quantity that is less than three orders of magnitude lower than the quantity of the RNA dose by weight.

This has been determined (and continues to be determined during production of lots) with a validated quantitative PCR assay.

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Fact #5 : DNA Fragments Can’t Integrate With Our Genome

The presence of residual DNA fragments does not mean that they will integrate into our genome. For one thing – these are DNA fragments that have been broken down by the DNase enzyme.

These DNA fragments can only enter the cell nucleus if there is an enzyme called integrase, is not present in any COVID-19 vaccine. So they simply cannot enter the cell nucleus, never mind integrate with DNA.

On top of that, the mRNA vaccines are injected into the muscle, whose cells are “post-mitotic”, which means they are no longer able to change.

Fact #6 : Viruses Integrate With Cell DNA

Viruses like SARS-CoV-2 and HIV-1 (diagram below) integrate their genes with the host cell DNA, to hijack the cell and use it to produce copies of itself.

You can see how a typical RNA virus would infect a host cell, convert its RNA into DNA which is moved into the cell nucleus using the integrase enzyme.

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HIV-1 virus cell infection
HIV-1 virus cell infection, credit : Günther Witzany

Once inside, the viral DNA integrates with the host cell DNA, which gets transcribed into instructions for the cell to produce copies of the virus.

This is the same way how the SARS-CoV-2 virus infects our cells, to produce copies of itself to infect even more cells.

If you are truly worried about anything modifying your cell’s DNA, you should try to avoid viral infections like COVID-19. Better still – vaccinate yourself, and get protected against COVID-19!

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Dr. Adrian Wong has been writing about tech and science since 1997, even publishing a book with Prentice Hall called Breaking Through The BIOS Barrier (ISBN 978-0131455368) while in medical school.

He continues to devote countless hours every day writing about tech, medicine and science, in his pursuit of facts in a post-truth world.

 

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