Can siRNA / RIBOTAC deactivate mRNA COVID-19 vaccines?!

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Can siRNA or RIBOTAC deactivate mRNA COVID-19 vaccines and shut off spike protein production?! Take a look at the viral claim, and find out what the facts really are!


Claim : siRNA / RIBOTAC Can Deactivate mRNA COVID-19 Vaccines!

People are sharing a post (archive) on X (formerly Twitter), which claims that siRNA (small interfering RNA) and RIBOTAC (ribonuclease targeting chimeras) can deactivate mRNA COVID-19 vaccines and shut off spike protein production!

McCullough Foundation : BREAKING – Our new study finds promising methods to deactivate mRNA COVID-19 vaccines and shut off spike protein production.

Small interfering RNA (siRNA) and ribonuclease targeting chimeras (RIBOTACs) are promising solutions to target, inactivate, and degrade residual and persistent vaccine mRNA, thereby potentially preventing uncontrolled Spike protein production and reducing toxicity.

The targeted nature of siRNA and RIBOTACs allows for precise intervention, offering a path to prevent and mitigate adverse events of mRNA-based therapies.

Recommended : Did COVID-19 Vaccines Cause Rise In Excess Deaths?!

Can siRNA / RIBOTAC deactivate mRNA COVID-19 vaccines?!


No Evidence siRNA / RIBOTAC Can Deactivate mRNA COVID-19 Vaccines!

Let’s take a look at the “study” by the McCullough Foundation, and find out what the facts really are!

Fact #1 : The Article Has Not Been Peer-Reviewed

The study in question is called Strategic Deactivation of mRNA COVID-19 Vaccines: New Applications for RIBOTACs and siRNA Therapy, written by Nicolas Hulscher, Peter McCullough, and Diane Marotta.

If you download and read this preprint article (PDF), you will realise that:

  • the “study” isn’t really a study, but more like an article, or an opinion piece,
  • no actual laboratory / clinical study was conducted,
  • it was a preprint – which means it has not been peer-reviewed,

Ironically, even anti-vaccine activists are pointing out that it was just an opinion piece:

Dr Jane Ruby : 🚨🚨 🚨 WARNING: This IS NOT A STUDY



This is not a peer reviewed scientific publication

You may recall Nicolas Hulscher and Peter McCullough as the authors of yet another preprint paper that was removed by The Lancet. I have no idea who Diane E. Marotta is, but she’s listed as an indepenent [sic] researcher out of Eagleville, Pennsylvania.

But if the authors cannot even get this paper past peer-review, no one should give a hoot about it, because even the peer-review process is merely the first step in the scientific review process.

Recommended : Did Study Show COVID-19 Vaccines Can Worsen Cancer?!

Kitten Facepalm

Fact #2 : No Evidence siRNA / RIBOTAC Can Deactivate mRNA COVID-19 Vaccines

The Hulscher et. al. paper envisions the use of siRNA (small interfering RNA) and RIBOTAC (ribonuclease targeting chimeras) to block and/or deactivate mRNA COVID-19 vaccines, and shut off spike protein production.

The problem is – there is no evidence that siRNA and/or RIBOTACs can actually do that. Outside of a nice diagram showing how they could possibly do that, no actual research was done to show that any of that could actually happen.

Charitably, these could be deemed as hypotheses on possible ways to destroy mRNA COVID-19 vaccines. Whether they would actually work though would require actual scientific research, not idle prattle in a preprint paper.

Fact #3 : It’s A Solution For A Problem That Does Not Exist

The Hulscher et. al. paper reads like a solution looking for a problem that does not exist. Despite its premise that the mRNA COVID-19 vaccine sticks around for a long time, that’s simply not true.

If the mRNA COVID-19 vaccines can persist, we would have years-long, if not lifelong, immunity. We would also not need a second dose, never mind a booster dose. Obviously, that is just not the case.

But more importantly – if mRNA COVID-19 vaccines are so “dangerous” (which they are not), then it would be much easier to simply not get vaccinated. Even anti-vaccine supporters and other people have pointed that logical fallacy out:

holykek : Oh neat a vaccine to cancel the vaccine 😵‍💫

Agus_Z_X : Wait a second, what you are saying doesn’t make any sense because @P_McCulloughMD knowingly or unknowingly is promoting gene therapy right here:

Sir Didimus : Urgh, talk about swallow the spider to catch the fly……

BitOhoney : Forget that other RNA stuff, here’s some other RNA stuff.

Simply put – there is no need for this siRNA / RIBOTAC treatment. If you are anti-vaccine, don’t get vaccinated.

Those who want to protect themselves against COVID-19 will want the vaccine to work, so it doesn’t make sense to stop the production of spike proteins, which is how the vaccines train our immune system to develop antibodies against the SARS-CoV-2 virus!

Recommended : Is new CKM syndrome caused by vaccine spike protein?!

Fact #4 : Viruses Multiply, Vaccines Won’t

I should also point out that if the spike protein is so dangerous, then it is even more important to get vaccinated against COVID-19. After all, viruses multiply, while the vaccines won’t!

Even if we simply look at the mRNA vaccines alone, they contain a limited number of mRNA instructions that encode for the SARS-CoV-2 spike protein. The mRNA instructions enter a limited number of cells, which then produce and display those spike proteins on their surfaces, to trigger our immune system.

If you are infected by the actual SARS-CoV-2 virus though, it quickly hijacks your cells to produce millions of copies – each covered with spike proteins, which then infect even more cells, in an ever-expanding chain reaction.

Until your immune system learns to stop and defeat the SARS-CoV-2 virus, it will keep producing millions and millions of viruses that will circulate through your body, delivering those nasty spike proteins everywhere.

So if you are really worried about the spike protein, you should really get vaccinated against COVID-19!

Please help us FIGHT FAKE NEWS by sharing this fact check article out, and please SUPPORT our work!

Don’t forget to protect yourself, and your family, by vaccinating against COVID-19!


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Dr. Adrian Wong has been writing about tech and science since 1997, even publishing a book with Prentice Hall called Breaking Through The BIOS Barrier (ISBN 978-0131455368) while in medical school.

He continues to devote countless hours every day writing about tech, medicine and science, in his pursuit of facts in a post-truth world.


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